Abstract
A series of new ribonucleosides 1a–d having 4-oxoquinoline-3-carboxylic acid substituted with a chloro or bromo atom in the aromatic ring, as the nitrogen base, was synthesized and examined for anti-HIV activity. Compounds 1a and 1c showed a modest inhibition activity on HIV-1 reverse transcriptase, inhibiting 10% of the enzyme activity at the concentration of 100 μM. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 197–202, 1999
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