Abstract
Treatment of 2-(2-bromoacetyl)-3 H-benzo[ f]chromen-3-one with pyridine, quinoline, and 2-methylquinoline afforded the corresponding pyridinium, quinolinium and 2-methylquinolinium bromides. The latter salts underwent [3 + 2] 1,3-dipolar cycloaddition with some electron deficient acetylene and ethylene derivatives to give the corresponding indolizine and pyrrolo[1,2- a]quinoline derivatives. Moreover, 2-(2-bromoacetyl)-3 H-benzo[ f]chromen-3-one reacted with arylidene cyanothioacetamides to afford the corresponding 2-amino-4,5-dihydrothiophene-3-carbonitriles. The synthesised compounds were characterised based on their elemental analysis and spectral data. Antimicrobial activity of some of the synthesised compounds was evaluated.
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