Abstract
A new set of thiazolyl-pyrazolines 3a–l was prepared by cyclization of carbothioamides 2a–g with phenacyl bromide and/or 4-bromo phenacyl bromide. The new chemical entities were tested for their antimicrobial properties, while none of the tested samples showed promising activity. The derivatives 2a–c demonstrated moderate potency against Staphylococcus aureus having the potential to be optimized into promising antimicrobial candidates. In addition to elemental analyses, the structural elucidation of the new analogues was carried out via IR, 1H NMR, 13C NMR as well as mass spectral data.
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