Abstract
Background: The aim of the study is to identify a novel furan-based chalcone derivativeas potent inhibitor against the H37Rv strain. Materials & methods: The in silico pharmacokinetic characteristics, toxicity tests, molecular modeling, chemical synthesis andminimum inhibitory concentration (MIC;IC50)were carried out to evaluate the antitubercular potential of the synthesized furan-based chalcone analogues against H37Rv. Results & conclusion: Among the ten target compounds synthesized, DF02, DF05 andDF07 hadMIC values of 1.6μg/ml equivalent to isoniazid and DF10 showed MIC values of 3.25μg/ml which is equipotent to pyrazinamide. All the other compounds hadoptimal concentrations 6.25-100μg/ml against the H37Rv strain. Compounds DF02 and DF10 werefurther evaluated for cytotoxicity assayperformed using HeLa cell lines.
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