Abstract
Some novel ferrocenylphosphine-amidine ligands with central and planar chirality were prepared from ( R, S p )-PPFNH 2-R 3 and its diastereomer ( S, S p )-PPFNH 2 3a. The efficiency and diastereomeric impact of these ferrocenylphosphine-amidine ligands in the palladium-catalyzed asymmetric allylic substitution was examined, and up to 96% e.e. with 98% yield was achieved by the use of ligand ( R, S p )- 4a with a methyl group in the amidino moiety. The results also indicated that ( R)-central chirality and ( S p )-planar chirality in these ferrocenylphosphine-amidine ligands were matched for the palladium-catalyzed asymmetric allylic alkylation.
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