Synthesis of novel cyano quinolone derivatives and their antibacterial activities

Abstract

Seven cyano 4-quinolone derivatives were synthesized 2 (A-G) and the synthesized compound's antibacterial activity was tested. Structural elucidation of the synthesized compounds was carried out by their mass, infrared and N.M.R analysis. Antibacterial activity was evaluated against six bacterial strains e.g. Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enterica and Pseudomonas aeruginosa. After the analysis of the antibacterial activity, it was inferred that compounds 2C and 2G were found to be more active against Gram-negative and Gram-positive bacteria and are found to be potential candidates for the antibacterial drug. A different approach of replacing the 6th position fluorine of the quinolone ring with the cyanide group was carried out. Compound 2E was found to be the most active with MIC values of 0.0047, 0.0031, 0.0013, 0.0011, 0.0008, 0.012 respectively. This research leads to the development of cyano4-quinolones.