Abstract
Chiral Schiff-bases prepared from chiral amino alcohols catalyze the enantioselective Henry (nitro aldol) reaction between nitromethane and p-nitrobenzaldehyde in the presence of Cu(OTf) 2 and Zn(OTf) 2. Zn(OTf) 2 promoted the reaction yield, while Cu(OTf) 2 promoted the enantiomeric excess. The highest enantioselectivities were observed with ligand 3 (44% ee) and ligand 5 (47% ee).
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