Abstract
Synthesis of novel C-2 substituted imidazoline derivatives having the norbornene/dibenzobarrelene skeletons
Highlights
The chemistry of heterocyclic compounds is one of the most complex and important branches of organic chemistry
The synthesis of C-2 substituted imidazolines such as nutlin compounds is of great importance in terms of both organic and medicinal chemistry because nutlin compounds are known to exhibit anti-tumor activity
Novel C-2 and N-acyl substituted imidazolines showing dibenzobarrelene or norbornene moieties were synthesized in this study for the first time
Summary
The chemistry of heterocyclic compounds is one of the most complex and important branches of organic chemistry. Since natural or synthetic originated imidazolines are found in the molecular structure of many drugs as biologically active residues, imidazoline compounds are extensively used in medicinal and pharmaceutical chemistry. Imidazoline compounds are widely studied by organic chemists with regard to their different application areas as synthetic intermediates, protecting groups, chiral auxiliaries and catalysts for asymmetric synthesis. In recent years, they have gained importance as organocatalysts[14,15,16] in very diverse stereoselective reactions due to their basicity and nucleophilicity[17] as well as Brønsted acidity[18,19] of their salts. Novel C-2 and N-acyl substituted imidazolines showing dibenzobarrelene or norbornene moieties were synthesized in this study for the first time
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