Synthesis of Novel bis-spirooxindoles Catalyzed by Magnetic Cobalt Ferrite Encapsulated MCM-41@MgO as a Solid Base.

Abstract

Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile, and various derivatives of cyclohexanones. A facile one-pot and four-component reaction was investigated for the synthesis of novel bisspirooxindoles from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild conditions. Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared in three steps. Afterwards, the CoFe2O4@MCM-41@MgO was used as a base catalyst for the one-pot synthesis of bisspirooxindoles. The procedure exhibited several benefits, an excellent yield of products, short reaction times, reusability, and recyclability of the nanocatalyst. The structure of nanocatalyst was recognized by FT-IR, XRD, VSM, SEM, BET, and EDX techniques, and the structure of the organic products was determined by melting point, FT-IR, 1H NMR, 13C NMR, Mass spectra, and C.H.N analyses.