Abstract
Synthesis of novel bis(nicotinecarbonitrile) derivatives
Highlights
Pyridine derivatives are an important class of azaheterocycle found in many natural products
As a consequence of this interest and in continuation of our work on Michael addition[30,31,32,33,34,35,36,37], multicomponent reactions[33,34,35,36,38,39,40,41,42,43,44] as well as on the synthesis of bis-heterocyclic with a suitable spacer[40,44,45,46,47,48,49,50,51,52,53,54], we report the results of our investigations concerning the synthesis of novel bis(nicotinecarbonitrile) derivatives
The 1H NMR spectra were recorded in DMSO–d6 as solvent on Varian Gemini NMR spectrometer at 400 MHz using TMS as internal standard
Summary
Pyridine derivatives are an important class of azaheterocycle found in many natural products. They have occupied a unique position in the field of medicinal chemistry (cf Figure 1)[1] due to their wide range of biological and pharmacological activities[2,3,4,5,6,7,8,9]. In this respect, some pyridine derivatives have been reported to exhibit antibacterial[10], antimicrobial11,12 , antifungal[13], cardiotonic[14], analgesic[15], antiinflammatory[16] and anti-lung cancer[17] activities. Some pyridine derivatives represent the most interesting heterocyclic units in some agrochemical targets (cf. Figure 2)[18,19,20]
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