Abstract
AbstractA synthesis of bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis‐ or poly(aldehydes) with o‐phenylenediamine or 2‐aminothiophenol, respectively, in ethanol at reflux in the presence of NaHSO3. The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF‐7), liver cancer cell line (HepG‐2), and epithelial colorectal adenocarcinoma cells (CaCO‐2). Hexakis(benzothiazole) was found to exhibit the highest activity against HepG‐2 and MCF‐7 cell lines with IC50 values of 21.16 and 13.25 μM, respectively.
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