Synthesis of novel 6-piperidin-1-ylpyrimidine-2,4-diamine 3-oxide substituted calix[4]arene as a highly selective and sensitive fluorescent sensor for Cu2+ in aqueous samples

Abstract

In this study, we designed and synthesized a novel sensitive fluorescent sensor for Cu2+ cation by attaching two minoxidil molecules at the lower-rim of calix[4]arene annulus via the formation of two urea linkages. This chemosensor can selectively recognize Cu2+ in EtOH containing 5% H2O through a significant decline in fluorescence emission. The structure of the target molecule was determined by HRMS, 1H NMR, 13C NMR and FT-IR.