Synthesis of novel 5,5’-(R-diylbis(sulfanediyl)) bis(3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole- 4-amines)

A A Safonov

doi:10.24959/ubphj.18.154

Abstract

Topicality. There is a tendency to increase the number of generics in comparison with the original drugs at the present national pharmaceutical market. A few new drugs registered which contain new substances. Thus, the already wellknown drugs appear under new names, while their pharmacological effect is not stronger and safer.The aim of this work was to synthesize and to study structure confirmation of novel 5,5’-(R-diylbis(sulfanediyl)) bis(3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amines).Materials and methods. There are synthesized new 5,5’-(R diylbis(sulfanediyl))bis(3-(thiophen-2-ylmethyl)-4H- 1,2,4-triazole-4-amines). Structure of substances was established by the modern physical and chemical methods of analysis (Elemental analysis, 1H-NMR-spectroscopy, HPLC-MS).Results and discussion. There are synthesized 5,5’-(R-diylbis(sulfanediyl))bis(3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amines) and 5,5’-(R-1,3-diylbis(sulfandiyl))bis (N-R-iden-3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amines.Conclusions. The structure of synthesized substances was established by the modern physical and chemical methods of analysis (Elemental analysis, 1H-NMR-spectroscopy, HPLC-MS)

Highlights

There is a tendency to increase the number of generics in comparison with the original drugs at the present national pharmaceutical market
The already well-known drugs appear under new names, while their pharmacological effect is not stronger and safer
Failures provide invaluable knowledge for researchers in creating new drugs. The solution to this issue is focused on synthesis and further development of new substances

Summary

Introduction

There is a tendency to increase the number of generics in comparison with the original drugs at the present national pharmaceutical market. A few new drugs registered which contain new substances. The already well-known drugs appear under new names, while their pharmacological effect is not stronger and safer. On average, it takes 10 years to develop the drug. Failures provide invaluable knowledge for researchers in creating new drugs. The solution to this issue is focused on synthesis and further development of new substances. One promising direction of finding new potential substances is the synthesis of 1,2,4-triazole derivatives[5,6,7]. Synthesis and structure confirmation of novel 5,5’(R-diylbis(sulfanediyl))bis(3-(thiophen-2-ylmethyl)-4H1,2,4-triazole-4-amines) were the purposes of our work

Objectives

Methods

Results

Conclusion