Abstract
Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.
Highlights
The use of 4-thiazolidinone as chemical fertilizers to increase the yield of crops and pesticides to eliminate all kinds of parasites able to attack the cultivation is becoming more and more important because of the great problem facing the world to provide food to an increasing population [1]
Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli
Its interest that Schiff’s base analogs of 4-amino-antipyrine exhibited antibacterial and cytotoxic activities [10]. Because of these important results and variables observations, the present work prompted us to synthesize some new Schiff’s bases derived from condensation of 4-amino-antipyrine with aromatic aldehydes followed by cycloaddition with thioacetic acid to obtain the thiazolidin-4-ones in view of their an enzymatic as inhibition of purine metabolism enzymes caused by E. coli
Summary
The use of 4-thiazolidinone as chemical fertilizers to increase the yield of crops and pesticides to eliminate all kinds of parasites able to attack the cultivation is becoming more and more important because of the great problem facing the world to provide food to an increasing population [1]. Its interest that Schiff’s base analogs of 4-amino-antipyrine exhibited antibacterial and cytotoxic activities [10] Because of these important results and variables observations, the present work prompted us to synthesize some new Schiff’s bases derived from condensation of 4-amino-antipyrine with aromatic aldehydes followed by cycloaddition with thioacetic acid to obtain the thiazolidin-4-ones in view of their an enzymatic as inhibition of purine metabolism enzymes caused by E. coli. Some strains of E. coli, for example, O157:H7, can produce Shiga toxin (classified as a bioterrorism agent) This toxin causes premature destruction of the red blood cells, which clog the body’s filtering system, the kidneys, causing hemolytic-uremic syndrome (HUS). For these reasons, we focused on synthesize some compounds act as inhibitors for E. coli [11]
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