Abstract
On the basis of molecular variations on isosteric replacements from the prototype 1-(2,3-dihydro-5 H-1,4-benzodioxepin-3-yl)-5-fluorouracil a series of 3-(2,3-dihydro-5 H-4,1-benzoxathiepin-3-yl)-uracil or -thymine O, N-acetals was prepared. The nature of the cis- and trans-sulfoxide isomers was established by means of their conformational analyses carried out with Sybyl and after comparing the theoretical results with the 1H NMR responses of the target molecules. ( RS)-3-(1,1-Dioxo-2,3-dihydro-5 H-4,1-benzoxathiepin-3-yl)thymine and (1 S*,3 S*)-1-(1-oxo-3,5-dihydro-2 H-4,1-benzoxathiepin-3-yl)thymine were found to be inhibitors of the MCF-7 cell growth.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
