Synthesis of non-enzymatic biosensor based on selenium dioxide nanoparticles in order to detection of glucose under electrochemical method

Abstract

In this project, a novel electrochemical biosensor was produced for the glucose recognition. Selenium dioxide Nanoparticle (SeNPs) synthesized a two-step process with a hydrothermal method. The SeNPs were characterized by X-ray diffraction (XRD). Also, the size distributions of nanoparticles were determined by dynamic light scattering (DLS), that more than 90 percent in the size range of 58–100 nm. The electrochemical performance of the SeNPs electrode for detection of glucose was investigated by cyclic voltammetry (CV). SeNPs show high electrocatalytic activity toward glucose oxidation in alkaline medium and are used for non-enzymatic electrochemical detection of glucose. The biosensor also had a linear response to glucose in the range of 0.5-2.5 mM and a low detection limit of 1.3 μM glucose (S/N=3). Therefore, the sensor shows great promise for simple, sensitive, and quantitative detection and screening of glucose and real sample (glucose in the human serum). This novel structured electrode holds great promise for the development of biosensors and other electrochemical devices.