Abstract
The synthesis of no-carrier-added 3-[ 18F]fluoroanisole, 2-[ 18F]fluoroanisole, [ 18F]fluorobenzene and 4-[ 18F]fluoroveratrole are reported. The strategy consists of amino-polyether supported nucleophilic substitution with [ 18F]F − on activated nitro aromatic aldehyde precursors followed by decarbonylation using Tris(triphenylphosphine) rhodium (I) chloride. The experimental parameters for this reaction have been studied and optimized with 2-[ 18F]fluoro-4-methoxybenzaldehyde and then successfully applied to four other 18F-fluorinated aromatic aldehydes. The decarbonylation yields obtained were 84 ± 5% (corrected for decay) within 15 min at 150°C in 1,4-dioxan.
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