Abstract
A method is described for the preparation of high specific activity [ 11C]methylamine. It was prepared by the hydrogenation-reduction of hydrogen [ 11C]cyanide using an Adams catalyst with H 2 gas in dilute sulfuric acid solution. The specific activity of [ 11C]methylamine was determined by HPLC as its 2,4-dinitrophenyl derivative. [ 11C]Methylamine was synthesized with a radiochemical yield of 50–70% within 20–25 min of the end of irradiation. Using a current of 30 μA of 20 MeV proton and a 30 min irradiation of the target gas ( N 2— H 2 mixture, 7 bar), 400–500 mCi of [ 11C]methylamine were obtained with a specific activity of 1.6–2.5 Ci/μmol. The material is available in the gas phase, or in aqueous or organic solution.
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Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
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