Synthesis of no carrier added [1- 11C]propenoic acid and derivatives

Abstract

The reproducible preparation of [1- 11C]propenoic acid (acrylic acid) in 45–50% radiochemical yield was made possible by careful control of the temperature and time of the 11C carbonation of ethenylmagnesium bromide. It allowed the obtention of [1- 11C]propenoyl chloride and N-[1- 11 C] substituted propenamides. These latter were highly reactive as it was shown by the obtention of a Michael adduct with secondary amines even at room temperature.