SYNTHESIS OF NITRO- AND AMINOINDOLES

Abstract

Optimal conditions are proposed for the direct nitration of 2,3-dimethylindoles containing methyl and methoxy groups in the benzene ring. In contrast to 5- and 6-methylindoles and 5- and 6-methoxyindoles, nitration of 7-methyl- and 7-methoxy-2,3-dimethylindoles proceeds differently under the same conditions. A series of previously unreported aminoindoles was obtained by reduction of the nitroindoles. Authors: S. A. Yamashkin and M. A. Yurovskaya. English Translation in Chemistry of Heterocyclic Compounds , 1999, 35 (12), pp 1426-1432 http://link.springer.com/article/10.1007/BF02251816