Abstract
The synthesis of β‐[2‐(alkoxyethyl)oxy]‐ and β‐[[2‐(N,N‐dialkylamino)ethyl]oxy]acetamides containing anN‐heteryl moiety is reported. Three heteryl systems, 2‐phenyl/methyl‐3,4‐dihydro‐4‐oxoquinazolin‐3‐yl, 5‐aryl‐1,3,4‐oxadiazol‐2‐yl, and 5‐alkyl‐1,3,4‐thiadiazol‐2‐yl, were employed. Appropriate heterylamines were first converted into their respective chloroacetamides and then reacted with 2‐alkoxyethanols/2‐(N,N‐dialkylamino)ethanols in dry acetone in the presence of anhydrous potassium carbonate to obtain the title compounds. Ten such new acetamides from each series were synthesized and characterized. Theirin vitroantihistaminic activity was determined using the isolated guinea pig ileum method. The IC50values of the compounds indicated correlations with their structural and electronic features.
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