Synthesis of New Thieno[2,3-b]pyridine Derivatives Based on Fused Thiophenes

Abstract

Conditions for the Gewald synthesis of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyrans from 2,2-dimethyltetrahydropyran-4-ones have been optimized, and the yields have been improved. A procedure has been developed for the synthesis of new pyrano[4′,3′:4,5]thieno[2,3-b]pyridines by the Thorpe–Ziegler reaction of thieno[2,3-c]pyrans. Anticonvulsant activity of the synthesized compounds was studied.