Abstract
Podophyllotoxin is a naturally occurring lignan compound which exhibits anticancer, anti AIDS and other biological activities. New tetralone ester intermediates of podophyllotoxin analogues were synthesised in very good yields by chalcone route. They were synthesized by replacing the 3,4,5-trimethoxy groups in podophyllotoxin respectively with hydrogen, methoxy and nitro group and also 1,3- methylene dioxy group with methyl thio group to study structure activity relationship. All the products were characterized by spectral and elemental analysis data.
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