Abstract
Abstract Synthetic efforts towards new tetracyclic heterocycles bearing the pyrrolo[2′,3′:5,6]azepino[4,3-b]indol-4(11H)-one core are described. Synthesized tetracyclic compounds are the first analogs, structurally related to protein kinase inhibitors paullones which incorporate an azepinone, an indole and a pyrrole ring. The synthetic approach involves palladium mediated intramolecular Heck coupling as a key step.
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