Synthesis of New Succinimides and Sulphonated Derivatives with Analgesic Action in Mice

Abstract

Recently, we have investigated the chemistry and biology of cyclic imides and have used phyllanthimide to obtain several analogues such as maleimides, succinimides and related compounds, which have demonstrated analgesic activity, amongst other properties. The work presented here describes the synthesis of new succinimides and their sulphonated derivatives. These substances were confirmed as having analgesic activity through abdominal constriction tests in mice. The results showed that some of the compounds, given intraperitoneally at a dose of 10 mg kg−1, were more effective than aspirin and paracetamol.