Abstract
In this research, novel derivatives of spiropyrrolo[3,4-b]pyridine derivatives were synthesized in high yields by using multicomponent reaction (MCR) of ninhydrin, ammonium acetate, ethyl 2,4-dioxo-4-arylbutanoates, primary amines, methyl propiolate, and triethyl amine (Et3N) in aqueous media. The antioxidant activity of new synthesized spiropyrrolo[3,4-b]pyridine derivatives is due to having OH group which was evaluated by two procedures. This employed procedure for preparation of spiropyrrolo[3,4-b]pyridine derivatives conveys benefits including reaction with low time, products with high yields, and easy separation of products using an easy procedure.
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