Abstract
Synthesis of new metronidazole derivatives with suspected antimicrobial activity
Highlights
لكنه غير فعال تجاه الجراثيم الهوائية،ميترونيدازول هو عامل قاتل للعديد من الجراثيم اللاهوائية سالبة وموجبة الغرام
Nakumura was discovered the aomycin group; Horie was demonstrated the anti-infective property of these compounds leading to their chemical synthesis in various laboratories throughout the world.[١]
Metronidazole is a bactericidal against anaerobic bacteria, its spectrum of activity includes the anaerobic gram negative bacilli including most Bacteroides, Fusobacterium and Veillonella, anaerobic gram positive cocci including
Summary
A (١٥٥ ml) of water and ٥٢ g of grease-free iron were placed in a (٥٠٠ ml) round bottom flask. The cold solution of ٤g, ٠.٠٥٨ mole sodium nitrite in ٢٠ ml water was placed in a separating funnel and added drop by drop to the stirred solution in an ice bath; the reaction temperature should be remain below ١٠°C by adding few grams of crushed ice when necessary. The solution was vigorously stirred and the temperature kept below ٥°C; this can be assisted by a direct addition of crushed ice. The cold diazonium salt solution (with few grams of crushed ice) was placed in a separating funnel and was added drop by drop to the stirred phenolic solution in an ice bath; yellow color will developed and yellow crystals soon separated giving compound II. After the diazonium salt solution was added; allow the mixture to stand in an ice bath for ٣٠ minutes; filtered off and washed the crystals three times with cold water, recrystalized from ethanol. As in a sensitivity test for aerobic bacteria, the same concentrations were applied and triplet runs were carried out
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