Abstract
The method of synthesis of fused thiopyridines via S-alkylation of the corresponding pyridine thiones with propargyl bromide has been elaborated. Fused enol tautomers have been obtained via the reaction of the prepared thiopropargyl pyridine compounds with acetylacetone in the presence of mercury(II) acetate followed by the reduction of intermediate organomercury compounds with alkali solution of sodium borohydride. Neurotropic activity of the synthesized compounds has been studied, and compounds with pronounced anticonvulsant activity have been identified.
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