Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity

Antonida V Kalistratova,Leonid V Kovalenko,Maxim S Oshchepkov,Alina M Gamisoniya,Tatiana S Gerasimova,Yuri A Demidov,Mikhail G Akimov

doi:10.1016/j.mencom.2020.03.007

Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity

Antonida V Kalistratova, Leonid V Kovalenko + Show 5 more

https://doi.org/10.1016/j.mencom.2020.03.007

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Journal: Mendeleev Communications	Publication Date: Mar 1, 2020
Citations: 8

Affiliation: D. Mendeleyev University of Chemical Technology of Russia, Institute of Bioorganic Chemistry

#Series Of Ureas #Neuroblastoma SH-SY5Y + Show 8 more

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Abstract

A series of aryl-substituted ureas and carbamates containing chlorinated aromatic and modified imidazolidinone moieties were synthesized. These compounds were found to be cytotoxic to breast cancer cell line MDA-MB-231, glioblastoma U-87 MG and neuroblastoma SH-SY5Y, but not to melanoma A-375.

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