Synthesis of new cadmium(II) complexes of Schiff bases as alkaline phosphatase inhibitors and their antimicrobial activity

Abstract

The present investigation deals with the synthesis, characterization and pharmacological evaluation of four cadmium complexes ( 1 – 4 ) with Schiff bases ( 1 L- 4 L) derived from the substituted amines and aryl aldehydes. Amantadine is reacted with different aryl aldehydes (salicylaldehyde, 3-ethoxysalicylaldehyde and 4-(diethylamino) salicylaldehyde) to prepare Schiff base ligands 1 L- 3 L, while 4 L was prepared using 4-methylaniline. The complexes were characterized by elemental analysis, spectroscopic techniques and thermal analysis, and the structure of one of the ligands, 3 L was determined by X-ray crystallography. The spectroscopic data indicate that the ligands coordinate with Cd(II) in a bidentate fashion to give octahedral geometry. Single crystal XRD analysis shows that 3 L is orthorhombic with the space group P2 1 2 1 2 1 . The ligands and their Cd(II) complexes were evaluated for antimicrobial activities, while the complexes were also investigated for inhibition effects towards an enzyme, alkaline phosphatase. The anti-microbial screening results showed that cadmium complex 1 exhibited significant antibacterial potential, particularly against Staphylococcus aureus with respect to the corresponding ligand suggesting that the complexes are more effective than their ligands for antimicrobial activity. In case of alkaline phosphatase inhibition screening, the synthesized cadmium complex 1 was found to maximally inhibit the activity of alkaline phosphatase in comparison to rest of three complexes.