Abstract
The proposed article relates to organic chemical synthesis and the study of new bromo-acetylene dithiocarbamates, the chemical properties of 1-isothiocyanate and 1-thiolacetylene esters of bromo-substituted benzoic acid, which are crystalline substances that are readily soluble in many organic solvents and insoluble in water. The structure of the bromine derivatives of acetylene dithiocarbamates was established by elemental analysis, IR and PMR spectroscopy. A probable mechanism of the interaction of 1-thiolpropargyl ethers with 1-isothioisocyanatepropargyl ethers is presented.With an increase in the nucleophilicity of the groups, the rates of addition and the yields of the final products increase, with a decrease in basicity and an increase in steric factors of the radicals, the rates of yield of the reaction products decrease slightly. Comparative tests show that the test derivative of the drug 1 - [(ortho-bromobenzoate-propynyl) -11- (ortho-bromobenzoate-propynyl) dithiocarbamate] showed a higher growth-promoting activity.
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