Synthesis of New 2′-(2- and 3-Aminopropanoyl)-6′,7′-dimethoxy-2′,3′-dihydro-1′H-spiro[cyclopentane-1,4′-isoquinoline]-1′-carboxamides

Abstract

6′,7′-Dimethoxy-N-methyl-2′,3′-dihydro-1′H-spiro[cyclopentane-1,4′-isoquinoline]-1′-carboxamide reacted with 2-bromopropanoyl chloride to give the corresponding 2-bromopropanamide which was converted to substituted 2-aminopropanoyl derivatives via reactions with cyclic secondary amines. The reaction of 6′,7′-dimethoxy-N-methyl-2′,3′-dihydro-1′H-spiro[cyclopentane-1,4′-isoquinoline]-1′-carboxamide with acryloyl chloride, followed by treatment of the resulting acrylamide with amines, afforded 3-aminopropanoyl derivatives.