Abstract
Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isothiocyanate as an electrophilic reagent for a general route to aminoglycoside‐coupled nucleic acid biopolymers is described.
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