Abstract

a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.

Highlights

  • Selaginella plana (S. plana) is one of the fern which becomes Indonesia’s biological wealth

  • Synthesis of nanoherbal from ethanol extract of S. plana Three nanoherbal formulas were synthesized from the ethanol extract of the fern S. plana, with variations in the mass of chitosan, namely 0.5% (F-1), 0.75% (F-2) and 1.0% (F-3)

  • The results of the synthesis showed that the three nanoherbal formulas were golden yellow colloidal liquids (Figure 1)

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Summary

Introduction

Selaginella plana (S. plana) is one of the fern which becomes Indonesia’s biological wealth. S. plana has been known and used by people as food (vegetables), ornamental plants, and as traditional medicine It has been used for postpartum care, treating wounds and bleeding, menstrual disorders, increasing the body immunity, as well as a postnatal tonic.[1,2,3] Traditionally, S. plana has been used to treat cancer, respiratory infections, liver disorders, urinary tract infections, fractures and rheumatism.[4] The Selaginella species on the island of Java has been found to contain secondary metabolites of the flavonoid group, with the highest content of biflavonoid compounds.[5] Biflavonoid compounds from ferns of the Selaginella genus have various bioactive properties, including antioxidants, anticancer, antibacterial, antiviral, antifungal, antimalarial, and anti-inflammatory properties.[3,6] As a phenolic compound, biflavonoid had been separated from several species of ferns in the Selaginellaceae family, namely amentoflavone, robustataflavone, ginkgetin, kayaflavone, podocarpus flavone, and hinokiflavone.[7,8,9,10,11,12]

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