Synthesis of N-5-Derivatives of Neuraminic Acid and Their Application as Sialosyl Donors

Abstract

As terminal constituents of glycoconjugates, sialic acids are involved in a wide range of biological phenomena. Different approaches and strategies have been developed to improve yield and stereoselectivity in sialylation reactions. Recently it has been reported that a substituent at the C-5 amino group in sialic acid influences the reactivity of both sialyl donors and acceptors. This review summarizes the latest accomplishments in sialylations using different N-substitued sialyl derivatives.