Abstract
Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including l- altro and d- galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated d- galacto iminosugars showed better inhibitory activities than l- altro analogues, which might hold potential as immunosuppressive agents.
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