Synthesis of N-Substituted 3-Chloro- 2-azetidinones for 2, 4-diamino-6- hydroxy pyrimidin

Abstract

This search involved synthesis of several new N-Substituted -3-chloro-
 2-azetidinones which were known as a high medicinal effectiveness for 2,
 4-Diamino-6-hydroxy pyrimidin in two steps. The first step included
 preparation Shiff bases (1-6) by condensation of 2, 4-Diamino-6-hydroxy
 pyrimidin with many substituted aldehydes(4-hydroxy benzaldehyde, 2-
 bromobenzaldehyde, 4-dimethyl amino benzaldehyde, = 4-nitro
 benzaldehyde, salicylaldehyde, 4-chlorobenzaldehyde), then the second
 step included, preparation new six azetidinones compounds (7-12) by
 reaction of chloroacetylchloride with the prepared Schiff bases in the first
 step in the presence of triethylamine. The structures of synthesized
 compounds were- characterized by physical properties (FT-IR, UV and
 some of them by 'H-NMR, C_NMR spectroscopy) were recorded.