Abstract
Abstract The synthesis of some N-(hydrogen methylphosphonothionyl) amino acid methyl esters (II-VII) and N-(O-methyl methylphosphonothionyl) amino acid methyl esters (VIII-XIII) is described. Reaction of methyl iodide with compounds (II-XIII) afforded the corresponding methyl iodide quaternary salt derivatives (XIV-XXV). All the synthesized compounds were found to possess high and moderate antimicrobial activities towards a number of microorganisms.
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