Abstract
AbstractA series of N‐homocyclylcarbamoyl derivatives of maleamic acid and maleimide was prepared for hypocholesteremic and sulfhydryl‐binding tests. The synthetic reactions involved in the controlled aminolysis of maleic anhydride with appropriate mono‐substituted ureas and the resulting carbamoylmaleamic acids were then thermally dehydrated to the corresponding carbamoylmaleimides. The monosubstituted ureas required in this synthesis were obtained by the action of amines on isocyanic acid produced in situ from nitrourea on heating in aqueous alcoholic solution.
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