Synthesis of n-alkylated derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones as potential anticonvulsants

Abstract

High psychotropic activity of pyrimidine derivatives attracts attention and directs the creation of new pyrimidine drugs which affect the central nervous system. As psychotropic agents a special attention deserve azolopyrimidine derivatives, including pyrazolopyrimidines. Thus, among the pyrazolopyrimidine derivatives had been found compounds with antiepileptic, anticonvulsant, sedative, anxiolytic activity [1, 2], ligands of benzodiazepine site of GABA receptors [3]. In addition, the ligands of 5HT-6 receptors were identified that are promising for the treatment of central nervous system, muscle relaxants [4]. The purpose of this research was a synthesis of alkylated derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4 H -pyrazolo[3,4-d]pyrimidine-4-ones.