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Abstract
A series of 5-halogenopyrimidinylsulfanilamides (I), possessing methyl, alkoxy, and/or alkylthio groups in the pyrimidine ring, were prepared from the corresponding N4-acetyl derivatives (II) by alkaline hydrolysis. Most of II were prepared from N4-acetyl-pyrimidinylsulfanilamide derivatives by halogenation with NBS or NCS, and the effect of substituents in the pyrimidine ring upon the halogenation reaction was clarified.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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