Synthesis of N‐α‐styrylcyclopropane‐5‐phenylamino‐1,2,4‐triazoles and their conversion to γ‐butyrolactones

Abstract

AbstractThe reaction of cyclopropyl phenyl ketone 1‐ureidoethylidenehydrazones 14 with a mixture of tri‐phenylphosphine, carbon tetrachloride, and triethylamine provides a general route to N‐α‐styrylcyclo‐propane‐5‐phenylamino‐1,2,4‐triazoles 17 via the thermal reaction of the expected azinocarbodiimide intermediates 15, and the oxidation of 17 with 3‐chloroperoxybenzoic acid affords 1,2,4‐triazole substituted y‐butyrolactones 23 directly.