Abstract
Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.
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