Abstract
Baylis–Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[ g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S N2′–S NAr elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.
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