Abstract

Incorporating Ag nanoparticles at core–shell Fe3O4@SiO2 provides promising opportunities for biomedical applications. Here, Fe3O4@SiO2-Ag nanoparticles have been successfully synthesized using seed-mediated growth methods. Based on the results, the as-prepared composite nanoparticles have good crystallinity and a core–shell structure. It was also revealed that the nanocomposites exhibited a superparamagnetic property with a magnetic saturation value ​​of 36.42 emu/g and surface plasmon resonance (SPR) absorption at 370 nm. Furthermore, the result also demonstrated that the as-prepared Fe3O4@SiO2-Ag showed an potential inhibition activity againstEscherichia coliandStaphylococcus aureuswith an inhibition zone of about 8–10 mm. In addition, an in-vitro MTS assay also revealed that epirubicin (EPI)-loaded Fe3O4@SiO2-Ag nanoparticles has cytotoxic properties against HeLa cells. This indicates that the as-prepared Fe3O4@SiO2-Ag nanoparticles could potentially be used as both an antibacterial agent and an anticancer drug carrier.

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