Abstract
In recent years, the combination treatment of chemotherapy and photothermal therapy (PTT) has emerged as an efficient approach to improve anticancer activity. Here, we combine zeolitic imidazolate framework-67 (ZIF-67) and CuSe to build a multifunctional therapeutic platform (ZIF-67@CuSe@PVP) with an efficient chemo-photothermal therapy for cancer treatment. ZIF-67@CuSe@PVP nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV-vis, Fourier transform infrared (FT-IR), and nitrogen adsorption-desorption isotherms. These nanoparticles exhibited excellent pH-responsive doxorubicin hydrochloride (DOX) releases due to the decomposition of ZIF-67 and excellent photothermal conversion efficiency (36%) without apparent deterioration during three cycles. In vivo biodistribution evaluation revealed the passive tumor-targeting ability of ZIF-67@CuSe@PVP@DOX via the enhanced permeability and retention (EPR) effect. Both in vitro and in vivo data demonstrated excellent anticancer efficacy of ZIF-67@CuSe@PVP in tumor-bearing mice. This multifunctional therapeutic platform could have certain clinical application potential.
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