Abstract
The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and 2,2′-azobisisobutyronitrile as an initiator and acetonitrile as a solvent. The synthesized imprinted and non-imprinted polymer particles were characterized by using Fourier-transform infrared spectroscopy and scanning electron microscopy. The rebinding efficiency of synthesized polymer particles was evaluated by batch binding assay. The highly selective imprinted polymer for gallic acid was MIPI1 with a composition (molar ratio) of 1:4:20, template: monomer: cross-linker, respectively. The MIPI1 showed highest binding efficiency (79.50%) as compared to other imprinted and non-imprinted polymers. The highly selective imprinted polymers have successfully extracted about 80% of gallic acid from spiked urine sample.
Highlights
Gallic acid (GA) is a polyphenolic naturally occurring compound in fruits such as blueberries, strawberries, apples, and bananas or other variety of plants and herbs such as oak bark, tea leaves and witch hazel
Materials and reagents Gallic acid (GA) and 2,2′-azobis(isobutyronitrile) (AIBN) were obtained from R & M Marketing company located in Essex, United Kingdom, acetonitrile was obtained from Avantor Performance Materials Incorporated located in Phillipsburg, New Jersey, acrylic acid (AA), ethylene glycol dimethacrylate (EGDMA) and syringic acid were obtained from Sigma-aldrich Corporated located in St
In this study five different polymers varying in chemical composition have been synthesized by precipitation polymerization using non-covalent approach
Summary
Gallic acid (GA) is a polyphenolic naturally occurring compound in fruits such as blueberries, strawberries, apples, and bananas or other variety of plants and herbs such as oak bark, tea leaves and witch hazel. Gallic acid is diversely used in various applications because of various pharmacological properties like antitumor and anti-inflammatory [1]. Gallic acid is main member of the polyphenolic family that provides vital antioxidant properties [2]. The extensive usage of gallic acid made an emphases on the researchers to design and develop new materials and/or approach for monitoring GA from different real samples. Molecular imprinting technology is a promising approach for the monitoring of gallic acid in real samples. Imprinted polymers are the cross-linked polymeric materials and are able to resist chemical and physical stresses such as organic solvents, heat, acid, The three binding approaches have been used in the synthesis of MIPs such as, covalent method, non-covalent method and semi-covalent method. Electrostatic interactions, hydrogen bonds and hydrophobic interactions are included in non-covalent forces used by both molecules of chemically and geometrically
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