Abstract
Effective synthesis of the tetrasaccharide 1, substrate for GlcNAc-T II, the pentasaccharide 9, substrate for GlcNAc-T III-V, and the modified analogues 2–8 and 10–14 are developed by linking the corresponding building blocks using the trichloroacetimidate method. The specific modified substrate analogues 2–8 and 10–14 can be applied to studies of the substrate specificity of GlcNAc-T II and GlcNAc T III-V, respectively. The modified tetrasaccharide 8 and the pentasaccharide 14 can be used also as potential specific substrate for GlcNAc-T IV and GlcNAc-T V, respectively.
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