Abstract
Manganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn0.5Zn0.5SmxEuxFe1.8−2xO4 (0.01 ≤ x ≤ 0.05) nanoparticles (NPs) by using the hydrothermal approach. The structure and surface morphology of the products were determined by X-ray powder diffraction (XRD), transmission electron and scanning electron microcopies (TEM and SEM), along with energy dispersive X-ray spectroscopy (EDX). We evaluated the impact of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 NPs on both human embryonic stem cells (HEK-293) (normal cells) and human colon carcinoma cells (HCT-116) (cancerous cells). We found that post-48 h of treatment of all products showed a significant decline in the cancer cell population as revealed by microscopically and the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium (MTT) assay. The inhibitory concentration (IC50) values of the products ranged between 0.75 and 2.25 µg/mL. When tested on normal and healthy cells (HEK-293), we found that the treatment of products did not produce any effects on the normal cells, which suggests that all products selectively targeted the cancerous cells. The anti-bacterial properties of the samples were also evaluated by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays, which showed that products also inhibited the bacterial growth.
Highlights
In recent years, spinel ferrites have attracted much attention from researchers due to their versatile magnetic properties and wide range of applications
We evaluated the impact of as-synthesized NPs on two cancer cell lines: HCT-116 and HEK-293
The lattice parameters and crystallite size were estimated by full proof refinement [26,27,28]
Summary
Spinel ferrites have attracted much attention from researchers due to their versatile magnetic properties and wide range of applications. Ferrites are most frequently used as magnetic absorbing materials owing to their cost effectiveness, excellent magnetic loss, and good stability [8]. Another advantage of nanosized spinel ferrites is that one can tune the magnetic properties by optimizing the size of the nanoparticles. Co-Zn-substituted spinel-type ferrites have been studied and found attractive for bio-medical applications because of their suitable room temperature magnetic properties [15,16]. The interface between the piezoelectric phase and the ferromagnetic phase is well established and leads to a high magnetoelectric coupling effect by reducing the coupling loss [17,18]
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