Synthesis of mixed secondary amino alcohols from oxazolidine derivatives

Abstract

The reaction of oxides (epichlorohydrin, glycidol methyl ether, and ethylene oxide) with oxazolid-2-one and 2-imino-5-methyloxazolidine has been studied. It has been established that the oxides add in position 3 of the oxazolidine ring with the formation of the corresponding S-(β-hydroxyalkyl) derivatives, the alkaline cleavage of which leads to mixed secondary amino alcohols.